Daniel McDaniel had a second marriage to Holland Guthrie Aug. 1839. He appears as head of house hold in 1840 Onslow Census. Holland (Guthrie) McDaniel, is listed as head of house hold in the 1850 US Federal Census, Stump Sound, Onslow County, North Carolina. They had one son together Isaac born in 1841. Daniel died after 1841 and before 1850.

This 1850 US Federal Census list Holland (Hollan sp.) (Guthrie) McDaniel as head of household, age 50, b. 1800, and family number 371 on page 112, living in Stump Sound, Onslow County, NC. Census was taken August 28, 1850. She is listed in column 12 as a female over 20 who cannot read or write.

Daniel McDaniel is listed as head of household in the 1840 Onslow County, NC Census but does not appear in this 1850 Census. He married Holland August 1839 and their son Isaac was born in 1841 so he probably died after 1841 and before 1850.

Daniel and Holland's son Isaac McDaniel is listed as age 9, b. 1841

Holland's son William J. Guthrie from a previous marriage is listed age 19 and a farmer.